![]() ![]() AAfter completing the prescreening questionnaire, people were deemed ineligible if they were currently using antidepressant medication (n = 157) lived outside reasonable commuting distance (n = 161) did not meet criteria for the magnetic resonance imaging scans (n = 99) had a first- or second-degree relative with a diagnosis of schizophrenia spectrum, bipolar I or II, or other psychotic disorder ( = 77) had a recent history of substance use disorder (n = 50) opted out of in-person screening (n = 38) were not in a current depressive episode (n = 37) were more than 25% beyond the upper or lower range of recommended body weight (n = 32) had a medically significant suicide attempt (n = 30) had lifetime hallucinogen use that exceeded the exclusion threshold (n = 30) if major depressive disorder (MDD) was not primary psychiatric diagnosis (n = 18) if they had a medical exclusion (n = 11) had exclusionary use of nonserotonergic psychoactive medication (n = 11) or failed to respond to electroconvulsive therapy during current depressive episode (n = 4). ![]()
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